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Copper-induced cell death

There are eight types of GPX family in mammals (GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GPX8), of which GPX1-4 and GPX6 of mammals are considered to be selenoproteins containing selenium, which have antioxidant functions, and GPX6 is only expressed in the human body ( In mammals, GPX works with superoxide dismutase and catalase to form an enzymatic antioxidant system that reduces reactive oxygen species (ROS) and limits their toxicity

This could demonstrate in fatigue, feeling tired all the time, an inability to think clearly, memory problems, experiencing seizures or falling into unconsciousness

The nuclear glutathione pool is more resistant to depletion by BSO than the cytosolic as it was demonstrated in 3T3 fibroblasts and other human cell lines 87,88 , hence we cannot exclude the possibility that AITC -which presumably acts differently from BSO- is able to deplete efficiently the nuclear pool

PMID: 23192413