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doi:10.1016/j.cell.2017.02.031

Topical application (well-studied): Serums at 0.1-0.5%, creams at 0.2-1%, hair products at 0.1-0.3%

Four -ketoacid dehydrogenase complexes ( Figure 4 ), including: (i) the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl-coenzyme A (CoA), an important substrate for energy production via the citric acid cycle