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In this regard, several studies generally attributed the anti-diabetic potential of PPs to their capability to reduce blood glucose level, improve insulin sensitivity and secretion, alleviate oxidative/nitrosative stress, inhibit carbohydrate digestive enzymes, alleviate -cells apoptosis, ameliorated lipogenesis, alleviate glucogenolysis and gluconeogenesis, up- and down-regulate of DM-associated genes, and modulate signaling pathways (NF-B, ERK, PPAR, AMPK, cytokines, protein tyrosine phosphatases, glucose transporter receptors, hepatic enzymes, tyrosine kinases, insulin receptors) (403406)

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In brain endothelial cells, exposure to Tat not only leads to transcriptional repression but also induces nuclear localization of ZO-1 through Rho signaling and CREB (Cyclic AMP Response Element-Binding Protein) activation

Radiosensitizers have been developed to amplify the effects of radiation within high-grade tumors, such as triple-negative breast cancer (TNBC) [9]