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In recent years, research on the application of glycyrrhizin in DILI has remained a focus of active research

10.1016/j.phymed.2022.154047 120 LuanY.WangM.ZhaoL.XuT.FuG.ZhangW

The clinical use of specific COX-2 inhibitor in the prevention or treatment of GC may be limited because of potential side-effects most notably within the cardiovascular system such as myocardial infarctions and elevation in blood pressure (92, 95)

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Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8