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Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis

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They heal in completely different ways

Whilst minor trauma and stress are common triggers, vitamin B12 deficiency represents an important yet often overlooked cause of persistent oral ulceration

Aging Cell 10 , 675685 (2011)