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Accumulation of intermediates such as succinate and fumarate can act as metabolic signals that stabilize hypoxia-inducible factor 1 (HIF-1) and amplify inflammatory cytokine production, thus coupling mitochondrial dysfunction to inflammation 112,113

Tesamorelin, a 44-amino-acid GHRH analog, is FDA approved for HIV-related lipodystrophy and is of interest in orthopaedics due to its anabolic effects on lean body mass

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The E156A and L330S mutants of hFSP1 were subsequently generated using site-directed mutagenesis

vivax cases diagnosed at the UKHSA Malaria Reference Laboratory, data are under accession codes PRJEB44419 and PRJEB56411