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Semin Radiat Oncol 28(3):194-200, 2018

Downregulated expression of Bmal1 was observed in SNCA A53T mice, a model for PD [162], suggesting that clock genes may be altered in PD

In short, cigarette smoking acts as a multifactorial disruptor, combining cytotoxicity, oxidative damage, hormonal imbalance, and apoptotic acceleration, to shorten reproductive lifespan and hasten the transition to menopause