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Fang et al., GSTs of unknown function in bacterial and yeast genomes (Vuilleumier and Pagni, 2002

S2CID 24403109

Hence, the benefit of having RNAi was proved to be selective disadvantage, thus creating RNAi-deficient fungi ( Neurospora crassa was first described as quelling by Romano and Macino (1992)

Furthermore, iron-mediated epithelial cell death promotes the secretion of various pro-fibrotic factors such as TGF-, CTGF, etc., inducing proliferation and differentiation of interstitial fibroblasts, ultimately leading to renal fibrosis