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A square planar environment around the metal center plays an important role in binding the superoxide radical anion at the metal center

Interestingly, several consensus sites for PAD have been identified in RG/RGG motifs

doi: 10.3389/fimmu.2025.1713426 Received 26 September 2025 Revised 13 December 2025 Accepted 19 December 2025 Published 24 March 2026 Volume 16 - 2025 Edited by Daniel P

This theory matches data from the German prospective multicenter study ALLIVE including 22 MDS and 90 AML patients and some smaller studies, which show an increase in NTBI and LIP levels during allogeneic HSCT ( During the course of AML, signs of iron overload have also been described