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Chen Y, Jiao L, Yan H, Xu W, Wu Y, Wang H, Gu W, Zhu C

By bilaterally injecting lentiviral vectors carrying siRNA targeting GSK-3 into the hippocampal dentate gyrus region to modulate GSK-3 activity, the study found that IF promoted neuronal differentiation and maturation in the dentate gyrus and improved the known dysfunction in 3xTg-AD mice

Beta-glucuronidase, an enzyme produced by the gut microbiome, can reverse the reaction that the UGT enzymes did to make the estrogen metabolites more water-soluble

Kota Sato, Tohoku University, Japan Updates Copyright 2023 Brooks, Kodati, Stankowska and Krishnamoorthy