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Pore-forming mediators such as gasdermins and NINJ1 were also not involved

pilosa aqueous extracts was found to be mildly toxic in acute and subchronic toxicity tests but caused no damage to vital organs, with an LD 50 greater than 5,000 mg/kg in rats (663)

ROS build up in stressed mitochondria has been proposed as a major player at the origin of NIHL (Bttger and Schacht, Figure 2)

This could be driven by increased ROS accumulation in cochlear cells, due for example to age-related decreases in mitochondrial membrane integrity (Shigenaga et al., 1994)

Siler U, Romao S, Tejera E et al (2017) Severe glucose-6-phosphate dehydrogenase deficiency leads to susceptibility to infection and absent NETosis