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Furthermore, the intervals between an inflammatory stimulus, the massive generation and complete activation of lytic enzymes, and the accumulation of glycocalyx degradation products, which causes changes in microvascular permeability that can be relatively prolonged (102)

26 doi: The effects of L-Citrulline and Glutathione on Endurance performance in young adult trained males. Authors: Cabre et al.

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While fewer trials have studied combinations of non-drug treatments, the reasoning is the same: therapies such as light therapy, shockwave therapy, electrical stimulation, vibration therapy, spinal decompression, and supplements all affect different parts of nerve health

This preserves the natural pulsatile release pattern and negative feedback mechanisms, typically resulting in a safer side effect profile (Prakash & Bhatt, 2013, Indian Journal of Endocrinology and Metabolism )