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Structure-guided compound optimization Structural biology-oriented chemical structure optimization After conducting a preliminary screening of a potential hit compound, it becomes imperative to optimize its structure via various synthetic strategies (such as bioisosterism, molecular hybridization, and scaffold hopping) to effectively increase its activity and improve its drug-like properties

It is a quaternary ammonium compound that the body synthesizes from the amino acids lysine and methionine, primarily in the liver, kidneys, and brain

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We also highlight potential avenues for future research that are aimed at improving the survival outcomes of patients with this disease

The use of the pons as a reference region for [ 11 C]Ro15-4513 PET has also been subject to criticism, since it may lead to the underestimation of target binding [19, 46, 47]