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The formulation process introduces variables that affect how much active peptide actually reaches the dermal target tissue

With that said, taking too much oral, intranasal, or intramuscular B12 may cause some of the following symptoms: Headaches Nausea and vomiting Diarrhea Tingling in the hands and feet Fatigue or weakness You should be aware of medication interactions with B12, such as metformin and proton pump inhibitors (PPIs)