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In sepsis-associated encephalopathy, mitochondrial dysfunction occurs in the setting of systemic inflammation, which contributes to increased blood-brain barrier permeability and resultant neuroinflammation [15, 16]

Conversely, clinical studies have demonstrated that GLS1 promotes mitochondrial respiration rate and tumour growth potential [17]

Patil, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Knowing how they differ can help you choose what's right for your skin

Hydroperoxides (ROOH) Hydroperoxides are unstable compounds formed via lipid (LOOH), protein (POOH), and DNA oxidation, originating primarily from three hepatic sources: (1) electron leakage from the mitochondrial electron transport chain (particularly Complex I/III), (2) ROS-generating activity of CYP2E1, and (3) the NOX enzyme family (predominantly NOX4)