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Notably, both IACS and FCCP reduce ATP production by blocking electron flow in the ETC, but have opposite effects on response to RSL3, either as co-treatment or administered prior to RSL3 treatment (Appendix Fig

Pigmentation-prone skin requires stricter maintenance

In addition to the system Xc - /GPX4 antioxidant axis, recent studies have found that GPX4-independent systems, such as the ferroptosis suppressor protein 1 (FSP1)/coenzyme Q 10 (CoQ 10 ) axis and the dihydroorotate dehydrogenase (DHODH)/CoQ 10 axis [38]

The NLRP3 inflammasomes are central to the initiation of inflammatory responses by activating caspase-1 and promoting the release of pro-inflammatory cytokines, particularly interleukin (IL)-1 and IL-18