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Specifically, the crypt base is characterized by high expression of the Wnt signaling molecule R-spondin, which promotes Treg proliferation

258,259 In senescent cells, the mitochondrial fission increases, causing the increase of dysfunctional mitochondria

Rezaie M, Nasehi M, Vaseghi S, Mohammadi-Mahdiabadi-Hasani MH, Zarrindast MR, Nasiri Khalili MA (2020) The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats