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Apart from clearance functions, high levels of acidification in synapses are also required for synaptic vesicle fusion and recycling 106 during neurotransmitter exocytic release 107 , which may explain why lysosomal enhancement via pH correction ameliorates synaptic dysfunction and cognition, as well as clearance of aggregate-prone proteins, in mouse models of AD and PD 94,108,109

The side effects of smoked Cannabis were similar to oral delta-9-THC with the addition of unacceptable levels of feeling high in some subjects [80]

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For instance, when we first alerted members to the dangers of high homocysteine levels, standard reference ranges indicated that blood levels of up to 15 mol/L were acceptable

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