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449 AKI-CKD represents a continuum, with spatial transcriptomics applied to a unilateral IR model at 1, 3, 14 and 28 days revealing that macrophages play a pivotal role throughout AKI-CKD

Garcia-Pavia et al., Reference Garcia-Pavia, Kim, Alejandra Restrepo-Cordoba, Lunde, Wakimoto, Smith, Toepfer, Getz, Gorham, Patel, Ito, Willcox, Arany, Li, Owens, Govind, Nunez, Mazaika, Bayes-Genis, Walsh, Finkelman, Lupon, Whiffin, Serrano, Midwinter, Wilk, Bardaji, Ingold, Buchan, Tayal, Pascual-Figal, de Marvao, Ahmad, Garcia-Pinilla, Pantazis, Dominguez, Baksi, ORegan, Rosen, Prasad, Lara-Pezzi, Provencio, Lyon, Alonso-Pulpon, Cook, SR, PJR, Aplenc, Seidman, Ky, Ware and Seidman2019)

More extensive studies are needed to confirm these observations in humans and to explore the exact mechanisms

Johansen CT, Wang J, McIntyre AD, Martins RA, Ban MR, Lanktree MB, Huff MW, Pterfy M, Mehrabian M, Lusis AJ, Kathiresan S, Anand SS, Yusuf S, Lee AH, Glimcher LH, Cao H, Hegele RA

Although PD is sporadic, extensive epidemiologic research associates environmental factors, such as chronic exposure to pesticides, with an elevated risk for lifetime development of PD