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This led to elevated levels of intracellular Fe 2+ , consequently facilitating the fibroblast-to-myofibroblast transition during the later stages of fibrosis

In hyperthyroidism there is: Increased serum T4, FT4 and T3 concen-trations, although occasionally T4 and FT4are normal and only T3 is raised Reduced serum TSH concentration in severe disease TSH can be undetectable Results expected in hypothyroidism are: Reduced serum T4 and FT4 concentrations (although both may be at the lower end of their reference ranges in the early stages of the disease) Increased serum TSH Some medicines (in addition to anti-thyroid drugs or thyroxine) can affect thyroid function 1 and, therefore, the results of thyroid function tests

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Reversing immunosuppression and restoring effective antitumor immune surveillance will help eliminate residual and drug-resistant tumor clones, thereby enhancing treatment durability and achieving more comprehensive therapeutic benefits for OSCC

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