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It is important that exogenous GSH not only significantly increased the content of total glutathione (by 40%) but also increased the endogenous content of its reduced form in cardiac tissue, thus contributing to maintenance of the redox potential of mitochondria and cardiac cells in general

In three consecutive enzymatic reactions, G6PDH (reaction 1), followed by 6-phosphogluconolactonase (6PGL, reaction 2) and 6PGDH (reaction 3), glucose-6-phosphate (G6P) is catabolised supplying cells with ribulose-5-phosphate maintaining the antioxidative power by generating 2 NADPH molecules

doi: 10.1007/BF02536638 15 DuffyS.AveryV