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Wang K, et al

196 When tumor cells metastasize to distant sites through the circulatory system, they are exposed to severe stress within the blood vessels, such as hemodynamic shear forces and attacks of the immune system

The liver is the main control center that contains the enzymes to facilitate this process

In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation

Kbc1 is an aceto-acetyl-CoA synthetase that also contributes to the AcCoA pool in C