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85 This was the first study to systematically link peptide secondary structure alterationsachieved via d-amino acid substitutionsto improved colonic delivery, offering a promising strategy for the oral administration of peptide therapeutics targeting colon-specific diseases such as IBD

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Mechanism of Action NNMT is a cytosolic enzyme that transfers a methyl group from SAM to nicotinamide, forming 1-methylnicotinamide (1-MNA) and thereby diverting nicotinamide away from the NAD salvage pathway