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Taken together, GLP-1based and dual GLP-1/GIP agonists represent a biologically plausible and clinically feasible strategy for repurposing as adjunctive neuroprotective therapies in PD, although further preclinical and clinical studies are needed to define their optimal dosing, treatment duration, and combinational approaches to ensure sustained neuroprotection (Figure 2)

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Despite DNA damage, the signals promoting cell death are not sufficiently activated, which is partly due to downregulation of cell death and upregulation of signaling preventing cell death

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