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Mobilisation of triacylglycerol stores

A.FangM

Intracellular signaling and secondary pathways MC1R-MC5R receptor activation primarily couples Gs but also recruits, to varying extents depending on the receptor and agonist, other pathways: Gq (phospholipase C, IP3, calcium), Gi under certain conditions (notably MC3R), and the ERK1/2 MAP kinase pathway via arrestin and EGFR transactivation