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Ageing alters the competence of the immune system to control parasitic infection

10.1371/journal.pntd.0011975 31 CavacoM.CastanhoM

In the context of cirrhosis, TNF- has been shown to downregulate the expression of type I collagen genes and directly counteract certain fibrogenic effects of transforming growth factor beta 1 (TGF-1), thereby demonstrating an anti-fibrotic effect 37,38,39,40,41 .This cytokine-mediated mechanism may elucidate how the elevated levels of TNF- observed in diverticular disease could contribute to an anti-fibrotic effect in cirrhosis