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The uncontrolled induction of iNOS by IFNy and the consequent increased production of NO can result in a greater oxidative load and cause nitrosative stress, possibly due to resistance to toxicity of glial cell cultures to high GSH levels in the microglia, and to up-regulation of Mn-SOD in the mitochondria in the course of the induction of i-NOS

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[DOI] [PubMed] [Google Scholar] 650

41, 137 (2022), Abstract Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation: K