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Description

Brain, kidney or liver (positive control) and lens tissue was collected at the same time (10am (ZT4)) and protein extracted

Evidence gap: A significant portion of the mechanistic data is derived from preclinical models (ovariectomized rodents)

The addition of SHLP3 to gentamicin-exposed explants resulted in a significant decrease in the immunofluorescence signals of p-AKT-S473 and p-AMPK-172 in both cochlear turns