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As the mitochondria produce energy (in the form of ATP), they also produce free radicals as a byproduct

Proctor, M

Moreover, Dysbiosis can trigger an inflammatory response, characterized by the release of pro-inflammatory cytokines such as TNF- , IL-6, and IFN- , these cytokines can directly affect the expression and distribution of TJ proteins (38)

Chen and colleagues reported that HSYA alleviated sepsis-associated pulmonary and intestinal injury by inhibiting TP53-mediated ferroptosis, linking HSYA to regulated cell death pathways that influence barrier integrity ( Several limitations should be acknowledged