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This process is primarily driven by the overexpression of COX-2 in OCSCs, which leads to an increased production of PGE2

Oral and topical glutathione are generally well tolerated in studies and appear to be safe at typical doses, although long-term data are limited

A previous study have identified a potential therapeutic strategy for LC, demonstrating that N-desmethyl imipramine hydrochloride modulate RBMS1 levels in IR-resistant LC cells, thereby enhancing their susceptibility to radiation therapy (119)

3.1 Glucose metabolism Lactate is a necessary byproduct of glycolysis, and tumor cells in the TIME are extremely dependent on glycolytic capacity, excreting large amounts of lactate, resulting in a localized low glucose, low oxygen, and acidic environment

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