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Finally, targeting autophagic process could also interfere with antiangiogenic therapy, frequently used in cancer

Pushpalatha et al., 2018a

Dark spot fading that is most important occurs around 3-4 months as pigmented cells shed through multiple turnover cycles [5]

However, if immune defenses are impaired (as occurs with age-related immune senescence), then pathogens are more likely to establish an infection (Brandenberger 2016