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Clinical Application Prospects for Vagus Nerve Stimulation Therapy Despite the good animal and clinical evidence for targeted plasticity therapy with VNS in various neurological diseases and brain injuries, the large-scale clinical use of VNS still faces many difficulties and challenges owing to the individual variability of clinical patients and the diversity of comorbidities

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The FDA did eventually approve these treatments

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The prevalence of liver granulomas is as high as 15% in biopsy specimens in the general population [2], with a higher frequency (up to 75%) in special populations like HIV-infected patients and patients with prolonged fever of unknown etiology [3]