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These results indicate that organic oxidants induce cardiomyocyte ferroptosis through GSH depletion and GPX4 downregulation

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PROTACs, heterobifunctional molecules comprised of functional ligands for POI and E3 ligases that are bridged by a linker, offer robust protein degradation/inhibition efficacy surpassing small-molecule inhibitors 35 , primarily owing to their catalytic nature 36