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Moreover, GDH1 is dispensable for the proliferation of noncancer cell lines including MRC-5 and HaCaT 19

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The results indicated that DZN exposure led to excessive reactive oxygen species (ROS) production and DNA damage, ultimately inducing apoptosis and autophagy by inhibiting the PI3K-Akt pathway [15]

Different cell lines were previously shown to vary in their allicin susceptibilities, which correlated with their intracellular GSH levels ( S -thioallylation of GSH and the formation of S -allylmercaptoglutathione (GSSA), which is accompanied by GSH depletion and an oxidative shift in the GSH redox potential ( Since Vero E6 cells are more sensitive toward allicin compared to Calu-3 cells, we first analyzed the effect of low levels of 50 M allicin on SARS-CoV-2 infected Vero E6 cells using pre- and post-infection treatments of host cells or pre-exposure of the virus before infection

Neufeld et al