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Recent studies demonstrated that Notch signaling is required for the adhesion of VSMCs but not other types of VSMC-derived cells in the formation of the cap in mouse atherosclerosis, and reduction of Notch signaling is a prerequisite for medial VSMC mediating the development of plaque, 248 suggesting that sequential loss and gain of Notch signaling is required for the recruitment of cap SMC population in atherosclerosis

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10.1111/febs.14138 50 PerrotT.SchwartzM.SaiagF.SalzetG.DumarayS.FavierF.et al (2018)

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However, when infectivity was assessed using equal amounts of viral input, viral particles from C7-treated cells consistently exhibited reduced infectivity compared to those from untreated cells across the entire range