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Understanding why this variability exists requires examining the mechanisms more closely

Front Immunol 13:880523 Sies H, Berndt C, Jones DP (2017) Oxidative stress

Oxidative stress or other stress stimuli induce the dissociation of the Nrf2-Keap1 complex, resulting in Nrf2 nuclear translocation and subsequent binding to the antioxidant response element (ARE) in the regulatory region of the target genes

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Four-in-one antibodies have superior cancer inhibitory activity against EGFR, HER2, HER3, and VEGF through disruption of HER/MET crosstalk