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It has been studied in preclinical models, cell cultures, and animal research for effects across a broader range of tissue types than most peptides of comparable size, including angiogenesis, nitric oxide signaling, and tendon, ligament, and muscle healing models

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The consistency of spatial dissimilarity of the ammonium removal capacity with the spatial heterogeneity of nitrifying guilds in RSF filters further supports the above hypothesis (Lee et al

elegans proteostressed neurons thus can serve as a validated model for deciphering the relative role of aggresomes in maintaining neuronal proteostasis and health in an in vivo context