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The premise underlying the leaky gut hypothesis is that physiologic stressors such as anxiety, intensive exercise, or dietary components such as emulsifiers increase intestinal mucosal paracellular permeability, enhancing entry of pathogenic bacteria and bacterial toxins into the systemic circulation, provoking systemic inflammation and triggering numerous diseases

These gaps underscore the need for more rigorous approaches, including gene-editing technologies, multi-omics analysis, and in vitro and in vivo models to elucidate the molecular mechanisms by which natural products may regulate autophagy and to assess their potential translational relevance in ovarian function preservation

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Phase II funds prototype development (typically up to $2M, ~24 months)

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