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A pregnane X receptor (PXR), a member of the steroid-retinoid-thyroid hormone receptor family, has recently been shown to mediate CYP3A induction by various chemicals (dexamethasone, rifampin, mifepristone, phenobarbital, atorvastatin, and hyperforin, a constituent of St

doi: 10.3390/molecules27061943 10 KhalkhaliMMohammadinejadSKhoeiniFRostamizadehK

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Interestingly, the observed transcriptional effects are strikingly similar to those observed in in vivo microarray studies during sleep deprivation, highlighting the importance of OX signaling for wakefulness and sleep deprivation [125]

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