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Considering our findings in the present study, in which we demonstrated that G translocates to the nucleus in response to repeated agonist stimulation of D2-like receptors, it will be particularly interesting to examine whether the expression of certain genes is regulated concomitantly with receptor desensitization and whether these genes are associated with the progression to pathological states induced in response to heightened receptor activation

Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability

doi: 10.1016/j.ijbiomac.2005.02.005

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Salvetti F, Rijal K, Owusu-Darko I, Prayogi S