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For participants taking hydroxyurea (HU), the dose of HU (mg) per kg should be stable for at least 90 days before enrolment, and with no anticipated need for dose adjustments (other than weight-based)

Theor Appl Genet 133:12011212

Pregnant or breastfeeding women should consult with their doctor before using this medication, as its safety in these situations is not well-established