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FT-iron levels in the striatum rise significantly, while TfR levels decrease, and FPN levels increase to manage the excess iron (Bartzokis et al., 2007

Ranasinghe SL, Fischer K, Zhang W, Gobert GN, McManus DP

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Kubelis-Lopez DE, Zapata-Salazar NA, Said-Fernandez SL, Sanchez-Dominguez CN, Salinas-Santander MA, Martinez-Rodriguez HG

Quite recently, experiments conducted using mice kidney and tubular cells showed that cisplatin-induced kidney inflammation might be governed by the activation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme which in the hyperactivated state decreases the rate of glycolysis and impairs electron transport and ATP formation, which eventually leads to dysfunction and/or death of various normal cell types