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Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Carcinogenesis, Mutagenesis, Impairment of Fertility Studies of lidocaine HCl in animals to evaluate the carcinogenic and mutagenic potential or the effect on fertility have not been conducted

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Many individuals can resume modified activity during mid-phase, with progressive loading helping direct tissue remodeling along functional lines

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Topiramate Cmax increased by 27% and AUC increased by 29% when HCTZ was added to topiramate