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This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder

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As a potential cancer treatment, it has also been observed that the effects of VIC on cancer are dependent on the route of administration, whether oral or intravenous, as well as on the mode of transport of VIC into tumoral cells (Figure 4)