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In these cases, the real issue is inflammation, which not only affects the muscles but can also lead to secondary injury mechanisms within the muscles themselves

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If left untreated, the capillary leakage and subsequent retinal hypoxia promote neovascularization [19], which manifests as PDR

In human 28% microglia renew per year, and microglial cells are on average 4.2 years old (Ru et al., 2017)

However, another study from Japan showed that the eradication effectiveness of first-line triple therapy with amoxicillin, clarithromycin, and vonoprazan decreased with age, possibly due to reduced gastric acid secretion in older patients, reducing the need for maintenance therapy with vonoprazan (Kusunoki et al., 2019)