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Studies have shown that MCs tend to accumulate around peripheral sensory nerve terminals (118), and their density is markedly increased in lesional AD skin (58), where they frequently remain in a highly degranulated state (119)

Instead, the Global Burden of Disease uses a big data approach to make broad estimates

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Because the chemical structure of nicotine is similar to that of acetylcholine, it is also able to activate cholinergic receptors