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Functional pathways related to amino acid metabolism, including glutamate and aspartate biosynthesis, were enriched in both groups

Oxford University Press: New York

Reduced nicotine strength or effect: Nicotine naturally oxidises as it ages, meaning you may feel a weakened experience or slower release Discolouration: Exposure to air and oxidation can cause the contents to look darker, faded, or patchy in colour Unusual smell: As flavour compounds break down, they can leave behind stale or off odours, signalling the pouch is past its best It's worth noting that using slightly expired pouches isn't harmful, it's simply a less enjoyable experience

The International Journal of Chronic Obstructive Pulmonary Disease , 14 , 100918

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