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The laser was disabled for 1 s to release the trapped particle and allow a new particle to diffuse into the confocal volume
For many developed (pro)drugs the ability to cross the BBB was shown by in situ perfusion techniques in rodents with a reported rate of permeation constant (K in )
145 One study has shown that inhibiting Drp1 activity by interrupting the Cox-2/Drp1 axis, reducing the stemness of NPC cells, and helping to increase its sensitivity to resveratrol and 5-flumidine treatment, 146 suggesting that targeting Drp1-dependent mitochondrial fission would be an effective treatment for NPC
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Besides being formed endogenously during lipid peroxidation, this aldehyde is inhaled with cigarette smoke and is present in cooked oils and other foods (Stevens and Maier, 2008)
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