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A study of 3D organotypic nasal epithelial culture showed that the impact of IQOS was substantially lower than CS in terms of cytotoxicity, tissue morphology, proinflammatory mediators, ciliary function, transcriptome perturbations, and miRNA expression profiles 59

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9 Consequently, many smokers continue to believe the tobacco in smooth, light or mild brands is different to that in original brands (i.e

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