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Figure 4 The glucose ketone index: a quantitative metabolic measure for monitoring nutritional ketosis in cancer and chronic disease management The GKI measures the millimolar ratio of circulating glucose to ketone bodies (HB) and is used to quantify the degree of nutritional ketosis (60, 68, 329)

Mol Psychiatry 28:284297 Frost G, Sleeth ML, Sahuri-Arisoylu M, Lizarbe B, Cerdan S, Brody L, Anastasovska J, Ghourab S, Hankir M, Zhang S, Carling D, Swann JR, Gibson G, Viardot A, Morrison D, Louise Thomas E, Bell JD (2014) The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism